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In small portions the stress hormone cortisol is amazingly helpful, however constantly raised ranges of it are unhealthy… for nearly every little thing. We’ve been performing some digging round in previous scientific journals, and happily there’s a simple approach to scale back the quantity of cortisol in your physique by thirty to forty %. Take 25 mg DHEA day by day, and Bob’s your [anticatabolic] uncle.

25 mg DHEA/day by day
The cortisol-reducing facet of DHEA supplementation just isn’t our personal discovery. A reader despatched us the YouTube clip beneath, during which Jeff Anderson advises males who wish to lose fats within the chest space to take 25 mg DHEA day by day. Fats deposition on this space is partly as a result of cortisol, says Anderson, and you’ll scale back your cortisol stage by taking a low dose of DHEA day by day.

Examine 1
Whether or not males can really lose pec fats by taking DHEA we don’t know, however the concept DHEA supplementation reduces the cortisol stage holds water. No less than, we discovered a research finished in 2003, during which researchers on the College of Pittsburgh acquired 69-year-old women and men to take 200 mg DHEA day by day for 15 days. [J Clin Psychopharmacol. 2003 Feb;23(1):96-9.]

Supplementation began on day eight and continued till day 22. The bars within the figures beneath present the quantity of cortisol within the blood of the individuals on every of these days.

The discount in cortisol stage on account of the DHEA was larger within the ladies than within the males. Though the boys’s cortisol ranges did go down, the discount was not statistically vital on all days.

Examine 2
A day by day dose of 200 mg DHEA is on the excessive aspect. Researchers use a dose of 50 mg DHEA per day in most research. In 2006 Italian researchers revealed the outcomes of a research on the impact of a significantly decrease dose of DHEA on cortisol ranges. [Gynecol Endocrinol. 2006 Nov;22(11):627-35.]

The Italians gave their take a look at topics – ladies aged between 50 and 55 [dark bars on the figure below] and between 60 and 65 [light coloured bars] – a day by day 25 mg DHEA for a interval of 12 months. 0 = cortisol stage earlier than DHEA supplementation began; 2 = after Three months; 3 = after 6 months; 4 = after 12 months.

The determine above reveals how DHEA supplementation may go. It reveals the impact of the administration of 10 micrograms ACTH on the cortisol stage, earlier than administration, and after 3, 6 and 12 months. ACTH is the messenger hormone that stimulates the adrenals to launch cortisol. ACTH secretion will increase underneath stress. It appears that evidently DHEA supplementation makes the adrenals much less delicate to ACTH.

Conclusion
For those who’re pondering of attempting to decrease your cortisol stage by taking DHEA, you’ll in all probability discover most impact in case you take the prohormone earlier than you fall asleep. Throughout your sleep your DHEA stage will peak. Your cortisol stage will even peak when you’re asleep, so inhibiting the cortisol will likely be handiest at that second. Sounds logical, doesn’t it?

Lengthy-term low-dose oral administration of dehydroepiandrosterone modulates adrenal response to adrenocorticotropic hormone in early and late postmenopausal ladies.

Summary

OBJECTIVE:
The getting older course of is related to a decline within the circulating Delta5-androgen dehydroepiandrosterone (DHEA) and its sulfate ester, dehydroepiandrosterone sulfate (DHEAS). The current research aimed to judge the consequences of a long-term (12 months) oral DHEA administration (25 mg/day) on adrenal operate, earlier than and after 3, 6 and 12 months of therapy.

METHOD:
Postmenopausal ladies belonging to 2 age teams, 50-55 years (n = 10) and 60-65 years (n = 10), have been studied. Adrenal operate was assessed in basal situations, after suppression with dexamethasone (DXM) and following a stimulation take a look at with adrenocorticotropic hormone (ACTH) (10 microg bolus). Serum ranges of DHEA, DHEAS, androstenedione (Delta4-A), allopregnanolone, 17-hydroxyprogesterone (17-OHP) and cortisol have been measured and the consequences of DHEA supplementation on particular adrenal enzymatic pathways have been evaluated by calculating precursor/product ratios (17-OHP/cortisol, 17-OHP/Delta4-A, DHEA/Delta4-A and DHEA/DHEAS).

RESULTS:
DHEA supplementation annulled the age-related variations in DHEA and DHEAS ranges and induced a marked improve in all steroids, aside from cortisol, after 3-6 months of therapy. Serum cortisol ranges decreased from the third month, each in youthful and older topics. DHEA supplementation didn’t have an effect on DXM-induced suppression of adrenal steroidogenesis. Throughout the therapy interval all adrenal androgens and progestins confirmed a major improve of their response to ACTH, whereas the cortisol response decreased considerably. The outcomes counsel a major DHEA-induced change in adrenal enzymatic actions, as additionally evidenced by the change in precursor/product ratios throughout remedy.

CONCLUSION:
Power DHEA administration is able to modifying circulating ranges of androgens and progestins in each early and late postmenopausal ladies by modulating the age-related modifications in adrenal operate.

PMID: 17145649 DOI: 10.1080/09513590601024681 [Indexed for MEDLINE]

Supply: https://www.ncbi.nlm.nih.gov/pubmed/17145649